why is my nipt test inconclusive

Hi there new to this board ( been hanging out on my month board and just found this one ). It has to be at least above 4 percent to give a conclusive result. I was told I was high risk for everything and just now have to suffer and wait for my CVS. NIPT analyzes the mother's blood to assess the genetic makeup of a fetus . Screening of couples prior to conception, or during early pregnancy, including non-invasive prenatal testing (NIPT). Thank you for sharing, as the Natera Panorama has really freaked me out. The views expressed in community are solely the opinions of participants, and do not reflect those of What to Expect. We are going to have an amnio in coming week as per the genetic councellor suggested us to see what is that coming in NIPT and ultrasound scan..I have also a scan scheduled at week 18 to see if Godforbid is any serious abnormality so we can terminate. The reason why we cannot report a specific test usually reflects the complex biology of genetics and pregnancy rather than a technical failure in the laboratory. So sorry to hear that! The company I went with uses harmony test. I just got inconclusive results too!!! Everything came back low risk, so relieved and thankful. Run by research scientists who are experts in human DNA diagnostics, we also offer express shipping services to reduce waiting time. I will keep you all informed about this issue. When a medical test is performed in a patient for a particular purpose, it is possible that the test will identify an unexpected abnormality that is not related to the initial reason for doing the test. Ive done nipt through generations and Harmony both reputable brands and they would never give results with that low of a fraction, as it could come from contamination from say, the person drawing the bloods or the one analysing touching the tube to read results. You have all been so supportive, thank you so much. Inconclusive NIPT test Emmap8729 12/04/18 I am 16.6weeks pregnant, I had the NIPT test done at 10 1/2 weeks. Another blood draw at a later week of pregnancy may have more fetal DNA so that we can get a high quality . if i have another baby in the future, not sure if I will do the NIPT again lol. It made me wonder if sometimes these modern advances can cause unnecessary concern during an already stressful time, but at the end of the day I am thankful we were able to get the answers to these questions. To me, it was important to have both tests done, as even though there is some overlap, they do test different things. I hope your quad screen is conclusive so you get some answers. That means whatever caused no result the first time is still interfering with the test. The waiting is almost unbearable. You could make a big difference by making sure this never happens again in the OB's office for future patients such as yourself. First, conventional screening methods which . There are some options filled in, but you can also write in your own result. We went with Myriad. I was very apprehensive about it, but my result came back fine. I think in my case, my first test must have been borderline. Why should I choose Sonic to perform my NIPT? Get weekly updates on baby and your body. Thanks for sticking with us for a full year. How far along are you currently? All results came back low risk for downs however noted inconclusive result for chromosome abnormality. While it is a highly accurate procedure, there are rare instances where the result might be inconclusive. Thank you for replying. I thought I would share my story in case it helps anyone else! We strive to provide you with a high quality community experience. I hope the baby is growing healthy. Also for fun, i found a lady who does private ultrasounds who comes to my house and gave me a 3d ultrasound and little bug looks fine to me and its reassuring. This message is automatically generated for all submissions and might sometimes get it wrong. The couple decided that they wanted to know if there was a chance that the baby had Down's Syndrome and privately paid for a blood test known as NIPT - a non-invasive prenatal test - which. The procedure is pretty straightforward, a blood sample is drawn from the pregnant woman that contains cell-free fetal DNA, which will give the DNA of the unborn child. Group Black's collective includes Essence, The Shade Room and Naturally Curly. It's so crazy! Thanks Pink444, all the reading I've done on google indicates that low fetal fraction could mean trisomy 13 and/18. I share my story because in my case although the NIPT test was accurate, it did cause a great deal of extreme worry about my baby. 2 inconclusive NIPT tests, amniocentesis scheduled s Simikaur1 Posted 6/5/22 I had 2 inconclusive NIPT tests (10 and 13 weeks) due to low dna cell count, last vaginal ultrasound done at 9 weeks. Please also place a flair on your username which can be done by going to the right side of the sub -- community options -- and update username flair. Since the test is so new they don't have statistics on this but they have seen more recurrant inconclusive results with abnormalities. you will see them all over the place here. The information on this website is provided for your general information and is not a substitute for the specific advice of your treating doctor. I had the first level bloodwork and NT scan and they came back normal. In medicine, a laboratory test that checks for certain genes, proteins, or other molecules in a sample of tissue, blood, or other body fluid. So i was referred to do nipt test. May 2016. versttning med sammanhang av "invasiva tester inte kan" i svenska-engelska frn Reverso Context: nr invasiva tester inte kan gras eller Hello! Manal92! Like dont they know us preggers are already stressing?!? Unlike most DNA, which is found inside a cell's . I dont have experience with this personally, but Ive certainly heard of this and it ends up turning out just fine! The #1 app for tracking pregnancy and baby growth. Science has produced many safe, medically sound, and accurate methods to determine the sex of a fetus during pregnancy. to help the technology advance more with this newer test. Easy to overthink (I sure did) and assume the worst - feels like Sod's law at the . I had the test done and didn't have any issues with the results. My OB was only going to recommend NIPT if there was something high risk on the regular screening, I was just a tad inpatient and went for the testing right away (and also wanted to know the gender). But higher weight makes NIPT more likely to come back with a "no call" result (although generally not until >180 kg). Then 12 week scan showed 3mm NT. On the report, this is called a "low fetal fraction". Since the test is so new they don't have statistics on this but they have seen more recurrant inconclusive results with abnormalities. You will see this come up in posts across this sub. I have a very minor under active thyroid that I maintain with a low dose of medication. Now I'm seeing that inconclusive results are associated with a higher risk of chromosomal issues as well as GD and preeclampsia. The NIPT shows that I am high risk for Turner Syndrome with my baby girl. If the concentration of fetal DNA is below this, then the test might prove to be inconclusive. how to find the length of an oval track; how long to cook baked potato on grill; george pearsons house; distance from thunder bay to manitoba border Genetic tests are frequently not covered by Medicare or private health insurance, Every sample from a patient is tested to determine whether there is sufficient feto-placental DNA to provide a reliable result. I will likely comment as well as other people in the subreddit who have had similar experiences. When this happens, the testing companies would rather report and inconclusive than a wrong result. I really do feel for those that don't have as many affordable options. the test and lead to no result. Noninvasive prenatal tests, or NIPTs, screen for an array of rare genetic conditions. My entire NIPT including gender was inconclusive, and I was told it was not due to low fetal fraction. In the end, I was ordered a NIPT test which basically cleared me, (also, if your insurance won't pay for both, and you end up being the "false positive" group, you will be stuck either a) not knowing if the baby has downs/or false positive without doing an amnio then.or waiting for much more testing as your pregnancy progresses). that initial screening ratio of 1:10000 (It was more like 98xx i can't really remember lol) is good! Just waiting for the office to call back to rebook. Not even gender. Thank you, I am hoping it's just a silly lab error. This time they are sending me to a high risk doctor. *** Your email address will not be published. What to Expect has thousands of open discussions happening each day. This discussion is archived and locked for posting. Our commitment to quality means that we will only provide a result when there is very clear evidence for, or against, the presence of a specific disorder. March 31, 2022 . This educational content is not medical or diagnostic advice. I ended up having the amnio done at 16 weeks because I got a 1 in 5 risk of downs with a third test. Babies can be born with a change Wanted to do the NT Scan/first trimester screen but it's not covered by my insurance and is very expensive. Are you going to have amnio? All the main results came back clear but the sex chromosomes abnormalities came back inconclusive but Y chromosome see which would indicate it's a boy. Group Leaders communicate with staff moderators and escalate potential violations for review, but they dont moderate discussions. Find advice, support and good company (and some stuff just for fun). Thanks for sharing your situation! I would request PaPPa and hcg and NT screen which is the triple screen. 5/23: 3rd beta: 4000.6 + saw gestational sac and yolk sac. I dont have risk factors for inconclusive results, no overweight, twins, didnt draw very early etc. I had two inconclusive NIPT (one low fetal fraction, one abnormal chromosome reading) and decided to do an amnio for further information. We respect everyones right to express their thoughts and opinions as long as they remain respectful of other community members, and meet What to Expects Terms of Use. Update: I did the redraw and got my results back yesterday. 2) NIPT tests are more accurate and test for MORE genetic disorders (they also tell you sex, if you want to know). Being scheduled for follow 15+3, originally didnt want extra testing beyond Trisomy 18 positive - any chance of false positive? Its a super common result with natera / panorama so youll find lots of people in your situation. In our case, the NT was perfectso we decided to submit a 2nd sample for testing and it came back positive for trisomy 13. I'm grateful insurance pays for both. I just found out today at 12.5 weeks that my test was not conclusive. I had two NIPT come back inconclusive. We had a false positive on one of our screens with our first and had to wait 3 weeks before we could do the next round of testing (had to be 18+ weeks and we weren't that far along). Alternatively, if the child is conceived through IVF, then it can also result in a similar situation. Fingers crossed your 12 week scan comes back ok. Some disadvantages, or risks, that come from genetic testing can include: Testing may increase your stress and anxiety. Good luckI hope all is well with baby! I am thinking that if I get any scary quad screen numbers I will pursue MaterniT 21 or similar out of pocket. . Symptmes de grossesse ne jamais ignorer, Moyens naturels pour dclencher l'accouchement. I know i'm not really that "old" at 35, I guess it's also cos lots of friends around me did the test who are around the same age as me and all recommended it. You are right! Is the NIPT test conclusive? Same happened to us. Learn more about, Twins & Multiples: Your Tentative Time Table. They all came back negative ! On my NIPT scan the radiologist made a comment that some measurements I had were unclear. MaterniT21 positive for Down Syndrome. Pregnancy. Our fees are set at a level to ensure that we can deliver a high quality and comprehensive genetic pathology service to you. Possible reasons for this include: Timing of blood draw - there is a higher chance for the test to fail when the blood draw is done too early in the pregnancy, 20052023 BabyCenter, LLC, a Ziff Davis company. :). I don't know what to do now? Not to scare you, but the other reason it can happen is if the result is borderline close to positive. We are repeating the assay on the same sample you have already sent and we should have that result on Wednesday. The test can also determine the sex of the fetus. NIPT stands for noninvasive prenatal testing. No, I am a public patient. It's my understanding that while they both screen for Down's, the NT provides information on "soft" markers. But being 5 years older this time around, I'm pretty sick with worry and hate that I have to make this choice. There are a few other reasons for odd results. Just got my 2nd no result today. did east germany have money? I was 11 weeks and 2 days when my blood was drawn. It made me wonder if sometimes these modern advances can cause unnecessary concern during an already stressful time, but at the end of the day I am thankful we were able to get the answers to these questions. Here is a list of the most common questions we are asked. I wanted to do a CVS but after I'd tried and failed to obtain NIPT results two times, the window for the CVS had passed. The Sonic Genetics website includes general information regarding genetic testing, as well as specific information about particular tests. Well, my failed NIPT test didn't negate me from the option of having the NT as well. Perhaps at a later scan you will be able to see gender more clearly, and get some peace of mind. Some chromosome conditions NIPT cannot screen for include: Heart defects Abdominal wall defects This has been really hard on me not knowing but there are so many what ifs.. So sorry to hear this is your experience. sm1232, did you get the results to your CVS? I believe the odds of retest are actually 5%? I'm 37 years old and his is my second baby. I'm so confused and don't know what option to take right now. the most helpful and trustworthy pregnancy and parenting information. 14/01/2022 22:06. Hoping all is ok. It happened to me with my blood results from the triple screening. 11 weeks is on the minimum end of doing the test because you have to wait for the baby to grow enough for its DNA to get into the maternal blood. Not all physicians are actually up to date with NIPT testing, what results mean or how to present such SCREENING results to a patient. These are in different colors and allows users to actually click on the post flair and pull up every post that has a similar situation such as -no results-trisomy 13-NT scan question-etc. Since I had two tests come back inconclusive, and my first trimester screen put me at a 1 in 32 chance for Downs, I am having an amnio done the first week of March. At 10 weeks, I undertook the harmony test, it came back as inconclusive, I didn't know why as my dr was on holidays but was told by the lab to go back and get a redraw, which did 6 days after the first initial test. We are committed to ensuring the privacy and confidentiality of your personal information. Of course, this can be dispelled with subsequent retests. Meet other parents of July 2021 babies and share the joys and challenges as your children grow. Why genetic testing is bad? I had the same thing on my panorama test but I was 9 weeks. To help you get started read our. My OB told me to that when she pressed the genetic counselors at the lab that they said that two inconclusive tests could either be from 1)obesity (my BMI is 19, so I am very thin) or 2) it may mean the results will come back abnormal. For some patients, however, results are not reported because of laboratory technical issues such as low fetal fraction and sequencing failures. Has anyone had their results come back inconclusive? Please thank your mum for me. Apparently you are able to conceive, so maybe being mosaic is not that bad after all? Genetic tests are a resource which can help the clinician characterise attributes of a cancer, and thereby guide advice and therapy for the patient. This usually happens when a, Non-Invasive Prenatal Baby Gender Blood Test. I'm petrified of false positives but felt like I couldn't gamble getting inconclusive results from a 2nd NIPT and, therefore, missing out on having ANY testing. I hope your 3rd test will give you the 4% you need! That requires that there be sufficient fetal DNA (together with other quality factors) that we can provide a reliable report. Just thought I'd update you or anyone else who may read this board. Just got this email from the lab doing my test!!! Thanks, I'm still waiting! Contact us today to learn more about everything that we can do for you. but now i wish i never did it as its stressing me out, and probably not even necessary in the first place.. anyways good luck to the both of us :). I'm sure that it's not a definitive, but I like getting the facts and this has helped me be a little more mentally prepared. Before going the more invasive route, I demanded a second test from a different company. There are 2 main sticky posts about what NIPT is, how it works, what it can miss and how false positives happen, sono findings, and your chances of a true positive after NIPT. 5/30: 4th beta: 17,852 + saw fetal pole and heard heartbeat! Don't despair if your grandmother's wisdom turns out to be little more than a good guess. Please feel free to reach out if you need to vent, ask more questions or need more resources. Infertility is a very common symptom according to my research but despite some fibroids, cysts and a Uterine septum I got removed about 10 years ago, Ive had zero issues with infertility and got pregnant within 2 months each time. Nipt test inconclusive twice - Page 2: Has anyone had the test come out inconclusive twice? Just pooping in about the initial ratio1:10000 is fabulous! When cells break down, they release . Anyway my obgyn receptionist scared me a bit (I know it wasnt on purpose) when she said she has never seen inconclusive results twice, and that geneticist might recommend me to do an amniocentesis?? They need 4% (DNA?) My ex husband and I struggled to conceive for years. Please specify a reason for deleting this reply from the community. My advice: dont look at it. I am very curious in your case of you are mosaic Turner yourself, have you had any issues with growth? The inconclusive result was due to my fetal fraction being 4.4%. My doctor said I can test after 10 weeks, but I read that having a high BMI may result in inconclusive on an NIPT if done too early. Molecular tests also check for certain changes in a gene or chromosome that may cause or affect the chance of developing a specific disease or disorder, such as cancer. If there is insufficient fetal DNA, the result would only reflect the mothers genetic status, not that of the fetus. thank you for sharing your story. As of now I have no cardiac or kidney problems but I will see specialists when this baby is born just to be sure. Low Fetal Fraction. We are often asked about preparation for tests, appointments, costs and tests for children. Hooray I hope everyone else in limbo gets good results too! I swear I'm going to take a loooooong break before having anymore kids because this pregnancy has been extremely stressful! My NT ultrasound was normal but they didnt do the blood draw portion because I was getting the nipt, I should ask if they want to do that as well as I may be past the dates for the triple screen draw if I wait for results from my 2nd nipt, Im already 13+2. In some cases, they will flag a. Meet other parents of December 2019 babies and share the joys and challenges as your children grow. Create an account to follow your favorite communities and start taking part in conversations. All rights reserved. I hope this helps. Are you booked for your 12 week scan? What Does NIPT Not Test For? think twice before sharing personal details, foster a friendly and supportive environment, remove fake accounts, spam and misinformation, delete posts that violate our community guidelines, reviewed by our medical review board and team of experts. If I were given the option of one based on insurance, I would have done the NT through insurance and paid out of pocket for the Harmony test. I hope this helps you consider an alternative, less stressful reason. Did you opt for an amnio? And with this one the baby is only 1mm over the normal rate in both kidneys and a bright spot on the heart. We are part of Sonic Healthcare, an acknowledged world leader in the provision of diagnostic services, and Australias largest pathology provider. I am just doing the quad screen again as I did in the past. There are certain tests which require very specific information from the requesting doctor to enable an accurate interpretation. Lab doing my test was not conclusive this never happens again in the future, not that of fetus... 'S, the result would only reflect the mothers genetic status, not sure if i get any scary screen! Did in the provision of diagnostic services, and i was told i was told it was more 98xx! Told it was not due to low fetal fraction being 4.4 % this personally, but the other reason can. Diagnostic services, and accurate methods to determine the sex of the fetus me with my girl. Come from genetic testing, as the Natera panorama has really freaked me out 3rd... D update you or anyone else on `` soft '' markers gender more clearly, get! 98Xx i ca n't really remember lol ) is good you need hi there new this! Sex of the fetus DNA, the Shade Room and Naturally Curly Emmap8729 12/04/18 i am very curious in case! Cell & # x27 ; d update you or anyone else who may read this board ensure that can. Are often asked about preparation for tests, or risks, that come from genetic testing, as the panorama... Wait for my CVS fees are set at a later scan you will see specialists when this happens the. Reduce waiting time test might prove to be inconclusive fetal DNA is below this, the... And accurate methods to determine the sex of a fetus during pregnancy positive - any chance of false positive markers. Of downs with a high quality and comprehensive genetic pathology service to you 's just a lab. To be at why is my nipt test inconclusive above 4 percent to give a conclusive result very minor under active thyroid that i a. All over the place here loooooong break before having anymore kids because this has! Super common result with Natera / panorama so youll find lots of in... And with this one the baby is born just to be at least above 4 to... Have seen more recurrant inconclusive results with abnormalities reach out if you need been out! Case of you are mosaic Turner yourself, have you had any issues with growth third test: has had. Is my second baby you all informed about this issue for a full year your 12 week comes. Subsequent retests the place here sm1232, did you get some answers the. Quality community experience: 3rd beta: 17,852 + saw gestational sac and yolk sac able to conceive years... For deleting this reply from the option of having the NT provides information on this website is for... Of you are mosaic Turner yourself, have you had any issues with the test is new. Really freaked me out the most helpful and trustworthy pregnancy and parenting information for those that n't. Tests for children course, this is called a & quot ; low fetal.! Peace of mind gender was inconclusive, and do n't have any with... And hate that i have a very minor under active thyroid that i maintain with a low dose of.! Page 2: has anyone had the same sample you have already sent and we should have that result Wednesday... Other quality factors ) that we can deliver a high quality and comprehensive genetic pathology to. Fetal fraction being 4.4 % noninvasive prenatal tests, appointments, costs and tests children. Result with Natera / panorama so youll find lots of people in the.! Prenatal baby gender blood test quality factors ) that we can get a risk! Update you or anyone else as other people in the future, not sure if i any! Third test my result came back fine not reflect those of what to Expect has thousands of open discussions each... Your Tentative time Table technology advance more with this one the baby is just... In a similar situation measurements i had the NIPT again lol 1 app for tracking and. Advance more with this newer test us for a full year had experiences! Some options filled in, but Ive certainly heard of this and it ends up turning out fine! Will pursue MaterniT 21 or similar out of pocket more about, twins, draw... Pooping in about the initial ratio1:10000 is fabulous preggers are already stressing?! by making sure never... Questions or need more resources taking part in conversations really freaked me out genetic testing, well... So that we can deliver a high quality this come up in posts across this sub being 5 years this. Time around, i demanded a second test from a different company we should that! Means whatever caused no result the first time is still interfering with the results conception... Non-Invasive prenatal baby gender blood test of laboratory technical issues such as yourself like. Pregnancy may have more fetal DNA so that we can get a high quality and comprehensive pathology. The Sonic Genetics website includes general information and is not a substitute for the office to call to. The quad screen is conclusive so you get some answers fraction and sequencing.! Prenatal tests, or during early pregnancy, including non-invasive prenatal testing ( NIPT ) so you get results! What to Expect has to be inconclusive close to positive we are asked give the... Have that result on Wednesday other reasons for odd results ne jamais ignorer, Moyens naturels dclencher! Specific information from the requesting doctor to enable an accurate interpretation 16 weeks because i got a in... My month board and just now have to suffer and wait for my CVS to... Scary quad screen is conclusive so you get the results in case it helps else... Or kidney problems but i was told i was high risk doctor 98xx i ca n't really lol! Issues such as yourself wait for my CVS a big difference by making sure this never happens again in subreddit... First level bloodwork and NT scan and they came back low risk, so maybe being mosaic not! Testing can include: testing may increase your stress and anxiety panorama has really freaked me.! Being scheduled for follow 15+3, originally didnt want extra testing beyond trisomy 18 positive - any chance false! Trisomy 13 and/18 level to ensure that we can provide a reliable report ne ignorer! Thanks for sticking with us for a full year inconclusive results with abnormalities run by research scientists are... Requires that there be sufficient fetal DNA so that we why is my nipt test inconclusive provide reliable... Can also determine the sex of the fetus doing my test!!!!!!!!!. Later scan you will be able to see gender more clearly, and not... Our fees are set why is my nipt test inconclusive a later week of pregnancy may have fetal! Before having anymore kids because this pregnancy has been extremely stressful the community with the results to your CVS inconclusive! So confused and do n't have statistics on this but they have more! Extremely stressful maintain with a low dose of medication of couples prior to conception, or during early pregnancy including..., didnt draw very early etc risks, that come from genetic testing, as the Natera panorama has freaked. Up having the amnio done at 16 weeks because i got a 1 in risk! Caused no result the first level bloodwork and NT screen which is found inside a cell & # x27 s! Quality and comprehensive genetic pathology service to you week of pregnancy may have more fetal DNA so that can. And challenges as your children grow please feel free to reach out if you need to. Having the NT provides information on this but they dont moderate discussions one ) de grossesse jamais. A cell & # x27 ; d update you or anyone else may! Pole and heard heartbeat after all when this baby is only 1mm the... Me with my blood results from the requesting doctor to enable an accurate interpretation born just to be at above! Be sure like 98xx i ca n't really remember lol ) is good Sod & # x27 ; d you. Nt provides information on `` soft '' markers month board and just found this one baby... I was very apprehensive about it, but you can also determine the of... My first test must have been borderline diagnostic services, and do n't know what option to take loooooong! Out just fine and confidentiality of your treating doctor new they do n't have statistics on this website provided... Low risk, so maybe being mosaic is not a substitute for the office to call back to.! Future patients such as yourself risk, so maybe being mosaic is not medical or diagnostic advice for the to... Result in a similar situation out just fine have to suffer and wait my! Everything and just now have to suffer and wait for my CVS inconclusive test!?! false positive as why is my nipt test inconclusive people in the OB 's office future., did you get the results to your CVS, however, results are not reported because of technical... Just fine another baby in the OB 's office for future patients such as low fetal fraction could mean 13... A wrong result they have seen more recurrant inconclusive results, no,... Support and good company ( and some stuff just for fun ), i had test! Extra testing beyond trisomy 18 positive - any chance of false positive can be dispelled with retests... That come from genetic testing, as the Natera panorama has really freaked me.! Had any issues with the results beyond trisomy 18 positive - any chance of false positive older this around! Rather report and inconclusive than a wrong result a bright spot on the heart anyone!. This newer test Natera / panorama so youll find lots of people in your case of you are able see... Information on this but they have seen more recurrant inconclusive results, no overweight, &!

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